Which of the following is NOT a reason to classify a pesticide as minimal exposure?

Classifying a pesticide as minimal exposure involves assessing various factors that might indicate a safer application for handlers and the environment. The effectiveness of the pesticide against pests does not play a role in determining whether it has minimal exposure risks. Instead, the focus of minimal exposure criteria revolves around handling practices, potential exposure levels, and the inherent toxicity of the product used.

The other factors mentioned are critical in assessing minimal exposure. Specific hazards not mitigated by labeling instructions highlight the importance of safe usage practices and appropriate hazard communication. Levels of potential handler exposure are directly related to how workers interact with the pesticide and help determine the risks involved. Similarly, the toxicity of the active ingredients is fundamental in understanding the inherent risks associated with the pesticide itself. Therefore, it's the effectiveness against pests that is unrelated to the classification of minimal exposure, making it the correct answer.